MEPhI scientists propose solution for blast cells’ classification in diagnostics of acute lymphoblastic leukemia

MEPhI scientists propose solution for blast cells’ classification in diagnostics of acute lymphoblastic leukemia September 27, 2016, 11:33

Currently diagnostics of acute leukemia is based on manual calculations of different types of cells by blood smears and bone marrow aspirations.

The data of morphological research, conducted by a doctor in the microscopic analysis of blood and bone marrow products, shows high variability of blast cells, and, as a consequence, leads to complications in identification of cell types and possible errors in diagnostics. In acute lymphoblastic leukemia assertion of presence of leukemia cells, morphologically similar to lymphoblasts in blood or bone marrow, requires conducting differential diagnostics with other lymphoproliferative diseases and reactive lymphocytosis. In a number of cases this is a difficult diagnostic problem.

Using of computer microscopy for classification of bone marrow and blood cells specifies characteristics of lymphocytes and leukemia blasts. MEPhI Department № 46 «Computer medical systems» specialists together with colleagues from Haematopoiesis Immunology Lab. of N. N. Blokhin Cancer Research Center have researched and shown applicability of the methods of texture analysis of images of nuclei chromatin for separation to blasts and lymphocytes with an aim of acute lymphoblastic leukemia diagnostics.

The results of work, for which the RF patent № 159002 was obtained, were used in the research.

The results of work can be used in getting additional independent criteria in acute lymphoblastic leukemia diagnostics.

According to Department № 46 post-graduate student E.v. Polyakov, blast differentiation from other types of blood cells, which can be found in periferic blood and bone marrow in the norm, is a planned stage of further research to raise the accuracy of haematological diseases’ diagnostics.

Source: https://mephi.ru/eng/content/news/1812/119017/

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