|
1
|
Gilead Sciences Inc.
|
USA
|
147.72B
|
|
2
|
Amgen Inc.
|
USA
|
111.95B
|
|
3
|
Celgene Corporation
|
USA
|
89.63B
|
|
4
|
Biogen Inc.
|
USA
|
65.46B
|
|
5
|
Regeneron Pharmaceuticals, Inc.
|
USA
|
52.32B
|
|
6
|
Alexion Pharmaceuticals, Inc.
|
USA
|
37.73B
|
|
7
|
Vertex Pharmaceuticals Incorporated
|
USA
|
29.18B
|
|
8
|
Illumina Inc.
|
USA
|
27.75B
|
|
9
|
Baxalta Incorporated
|
USA
|
23.25B
|
|
10
|
Grifols, S.A.
|
Spain
|
20.46B
|
|
11
|
BioMarin Pharmaceutical Inc.
|
USA
|
19.28B
|
|
12
|
Incyte Corporation
|
USA
|
17.57B
|
|
13
|
Jazz Pharmaceuticals Public Limited Company
|
Ireland
|
9.93B
|
|
14
|
Alnylam Pharmaceuticals, Inc.
|
USA
|
7.85B
|
|
15
|
Receptos, Inc.
|
USA
|
7.32B
|
|
16
|
Medivation, Inc.
|
USA
|
6.95B
|
|
17
|
Opko Health, Inc.
|
USA
|
5.58B
|
|
18
|
Anacor Pharmaceuticals, Inc.
|
USA
|
5.39B
|
|
19
|
Seattle Genetics, Inc.
|
USA
|
4.86B
|
|
20
|
Intrexon Corporation
|
USA
|
4.67B
|
|
21
|
bluebird bio, Inc.
|
USA
|
4.35B
|
|
22
|
Intercept Pharmaceuticals, Inc.
|
USA
|
4.35B
|
|
23
|
Ultragenyx Pharmaceutical Inc.
|
USA
|
3.62B
|
|
24
|
Juno Therapeutics Inc.
|
USA
|
3.53B
|
|
25
|
Bio-Techne Corp.
|
USA
|
3.52B
|
|
26
|
ACADIA Pharmaceuticals Inc.
|
USA
|
3.38B
|
|
27
|
Dyax Corp.
|
USA
|
3.11B
|
|
28
|
Agios Pharmaceuticals, Inc.
|
USA
|
3.05B
|
|
29
|
Novavax, Inc.
|
USA
|
2.89B
|
|
30
|
Puma Biotechnology, Inc.
|
USA
|
2.64B
|
|
31
|
Clovis Oncology, Inc.
|
USA
|
2.56B
|
|
32
|
Radius Health, Inc.
|
USA
|
2.44B
|
|
33
|
China Biologic Products, Inc.
|
China
|
2.29B
|
|
34
|
Portola Pharmaceuticals, Inc.
|
USA
|
2.25B
|
|
35
|
INSYS Therapeutics, Inc.
|
USA
|
2.24B
|
|
36
|
Halozyme Therapeutics, Inc.
|
USA
|
2.15B
|
|
37
|
Kite Pharma, Inc.
|
USA
|
2.14B
|
|
38
|
Chimerix, Inc.
|
USA
|
2.08B
|
|
39
|
Tesaro, Inc.
|
USA
|
1.78B
|
|
40
|
NantKwest, Inc.
|
USA
|
1.76B
|
|
41
|
Ligand Pharmaceuticals Incorporated
|
USA
|
1.65B
|
|
42
|
Amicus Therapeutics, Inc.
|
USA
|
1.59B
|
|
43
|
Alder Biopharmaceuticals Inc.
|
USA
|
1.57B
|
|
44
|
Prothena Corporation plc
|
Ireland
|
1.54B
|
|
45
|
Theravance Inc.
|
USA
|
1.53B
|
|
46
|
Ophthotech Corporation
|
USA
|
1.52B
|
|
47
|
MannKind Corp.
|
USA
|
1.48B
|
|
48
|
Seres Therapeutics, Inc.
|
USA
|
1.48B
|
|
49
|
Cempra, Inc.
|
USA
|
1.46B
|
|
50
|
Sage Therapeutics, Inc.
|
USA
|
1.46B
|
|
51
|
Insmed Incorporated
|
USA
|
1.40B
|
|
52
|
Sarepta Therapeutics, Inc.
|
USA
|
1.37B
|
|
53
|
FibroGen, Inc.
|
USA
|
1.32B
|
|
54
|
Cambrex Corporation.
|
USA
|
1.31B
|
|
55
|
Celldex Therapeutics, Inc.
|
USA
|
1.27B
|
|
56
|
Emergent BioSolutions, Inc.
|
USA
|
1.27B
|
|
57
|
Nektar Therapeutics
|
USA
|
1.26B
|
|
58
|
Acorda Therapeutics, Inc.
|
USA
|
1.24B
|
|
59
|
NewLink Genetics Corporation
|
USA
|
1.23B
|
|
60
|
Ariad Pharmaceuticals Inc.
|
USA
|
1.22B
|
|
61
|
Lexicon Pharmaceuticals, Inc.
|
USA
|
1.21B
|
|
62
|
Aduro BioTech, Inc.
|
USA
|
1.18B
|
|
63
|
Esperion Therapeutics, Inc.
|
USA
|
1.17B
|
|
64
|
Forward Pharma A/S
|
Denmark
|
1.16B
|
|
65
|
Exelixis, Inc.
|
USA
|
1.15B
|
|
66
|
PTC Therapeutics, Inc.
|
USA
|
1.12B
|
|
67
|
Axovant Sciences Ltd.
|
Bermuda
|
1.11B
|
|
68
|
ImmunoGen, Inc.
|
USA
|
1.10B
|
|
69
|
Global Blood Therapeutics, Inc.
|
USA
|
1.10B
|
|
70
|
Atara Biotherapeutics, Inc.
|
USA
|
1.09B
|
|
71
|
Coherus Biosciences, Inc.
|
USA
|
1.07B
|
|
72
|
Repligen Corporation
|
USA
|
1.06B
|
|
73
|
ZIOPHARM Oncology, Inc.
|
USA
|
1.04B
|
|
74
|
Merrimack Pharmaceuticals, Inc.
|
USA
|
1.03B
|
|
75
|
Spark Therapeutics, Inc.
|
USA
|
1.01B
|
|
76
|
Cellectis S.A.
|
France
|
992.73M
|
|
77
|
Achillion Pharmaceuticals, Inc.
|
USA
|
988.83M
|
|
78
|
Dynavax Technologies Corporation
|
USA
|
979.20M
|
|
79
|
Raptor Pharmaceuticals Corp.
|
USA
|
953.05M
|
|
80
|
Relypsa, Inc.
|
USA
|
947.84M
|
|
81
|
Intra-Cellular Therapies, Inc.
|
USA
|
906.30M
|
|
82
|
Zafgen, Inc.
|
USA
|
905.54M
|
|
83
|
Acceleron Pharma, Inc.
|
USA
|
898.90M
|
|
84
|
MacroGenics, Inc.
|
USA
|
896.04M
|
|
85
|
PDL BioPharma, Inc.
|
USA
|
865.23M
|
|
86
|
Aimmune Therapeutics, Inc.
|
USA
|
849.08M
|
|
87
|
BioCryst Pharmaceuticals, Inc.
|
USA
|
834.20M
|
|
88
|
ProNAi Therapeutics, Inc.
|
Canada
|
807.48M
|
|
89
|
Adaptimmune Therapeutics plc
|
United Kingdom
|
786.10M
|
|
90
|
Array BioPharma Inc.
|
USA
|
741.98M
|
|
91
|
Enanta Pharmaceuticals, Inc.
|
USA
|
728.19M
|
|
92
|
Epizyme, Inc.
|
USA
|
721.62M
|
|
93
|
Revance Therapeutics, Inc.
|
USA
|
709.40M
|
|
94
|
Blueprint Medicines Corporation
|
USA
|
707.57M
|
|
95
|
Omeros Corporation
|
USA
|
682.40M
|
|
96
|
Dermira, Inc.
|
USA
|
677.33M
|
|
97
|
Xencor, Inc.
|
USA
|
673.83M
|
|
98
|
TG Therapeutics, Inc.
|
USA
|
673.69M
|
|
99
|
Albany Molecular Research Inc.
|
USA
|
672.13M
|
|
100
|
Arena Pharmaceuticals, Inc.
|
USA
|
657.74M
|
|
101
|
Aratana Therapeutics, Inc.
|
USA
|
592.04M
|
|
102
|
Keryx Biopharmaceuticals Inc.
|
USA
|
587.90M
|
|
103
|
Northwest Biotherapeutics, Inc.
|
USA
|
587.13M
|
|
104
|
OncoMed Pharmaceuticals, Inc.
|
USA
|
586.77M
|
|
105
|
Osiris Therapeutics, Inc.
|
USA
|
586.17M
|
|
106
|
XBiotech, Inc.
|
USA
|
583.63M
|
|
107
|
Agenus Inc.
|
USA
|
553.85M
|
|
108
|
ANI Pharmaceuticals, Inc.
|
USA
|
549.71M
|
|
109
|
Chiasma, Inc.
|
USA
|
547.38M
|
|
110
|
Otonomy, Inc.
|
USA
|
534.58M
|
|
111
|
OvaScience, Inc.
|
USA
|
516.85M
|
|
112
|
uniQure N.V.
|
Netherlands
|
514.53M
|
|
113
|
Cara Therapeutics Inc.
|
USA
|
511.42M
|
|
114
|
NeuroDerm Ltd.
|
Israel
|
502.06M
|
|
115
|
Sangamo Biosciences Inc.
|
USA
|
499.50M
|
|
116
|
Five Prime Therapeutics, Inc.
|
USA
|
491.81M
|
|
117
|
Aegerion Pharmaceuticals, Inc.
|
USA
|
487.40M
|
|
118
|
Corcept Therapeutics Incorporated
|
USA
|
481.12M
|
|
119
|
Anika Therapeutics Inc.
|
USA
|
480.16M
|
|
120
|
Geron Corporation
|
USA
|
475.24M
|
|
121
|
Pfenex Inc.
|
USA
|
472.31M
|
|
122
|
Inovio Pharmaceuticals, Inc.
|
USA
|
471.60M
|
|
123
|
Progenics Pharmaceuticals, Inc.
|
USA
|
469.36M
|
|
124
|
Vanda Pharmaceuticals, Inc.
|
USA
|
460.12M
|
|
125
|
Spectrum Pharmaceuticals, Inc.
|
USA
|
459.73M
|
|
126
|
Sorrento Therapeutics, Inc.
|
USA
|
448.97M
|
|
127
|
La Jolla Pharmaceutical Co.
|
USA
|
443.47M
|
|
128
|
Ocular Therapeutix, Inc.
|
USA
|
439.52M
|
|
129
|
Bellicum Pharmaceuticals, Inc.
|
USA
|
437.35M
|
|
130
|
Ascendis Pharma A/S
|
Denmark
|
433.98M
|
|
131
|
Ardelyx, Inc.
|
USA
|
433.38M
|
|
132
|
Cerus Corporation
|
USA
|
429.75M
|
|
133
|
Infinity Pharmaceuticals, Inc.
|
USA
|
420.49M
|
|
134
|
Theravance Biopharma, Inc.
|
Cayman Islands
|
417.12M
|
|
135
|
Advaxis, Inc.
|
USA
|
411.52M
|
|
136
|
Paratek Pharmaceuticals, Inc.
|
USA
|
397.73M
|
|
137
|
Xenoport, Inc.
|
USA
|
377.16M
|
|
138
|
Arbutus Biopharma Corporation
|
Canada
|
376.51M
|
|
139
|
Ignyta, Inc.
|
USA
|
371.18M
|
|
140
|
IGI Laboratories, Inc.
|
USA
|
362.09M
|
|
141
|
Regulus Therapeutics Inc.
|
USA
|
357.73M
|
|
142
|
Mirati Therapeutics, Inc.
|
USA
|
354.34M
|
|
143
|
Genocea Biosciences, Inc.
|
USA
|
335.04M
|
|
144
|
Pacific Biosciences of California, Inc.
|
USA
|
332.91M
|
|
145
|
Inotek Pharmaceuticals Corporation
|
USA
|
327.62M
|
|
146
|
BioDelivery Sciences International, Inc.
|
USA
|
325.71M
|
|
147
|
Concert Pharmaceuticals, Inc.
|
USA
|
325.51M
|
|
148
|
aTyr Pharma Inc.
|
USA
|
324.34M
|
|
149
|
BioSpecifics Technologies Corp.
|
USA
|
321.27M
|
|
150
|
ProQR Therapeutics N.V.
|
Netherlands
|
311.10M
|
|
151
|
Loxo Oncology, Inc.
|
USA
|
305.59M
|
|
152
|
Curis, Inc.
|
USA
|
301.99M
|
|
153
|
Idera Pharmaceuticals, Inc.
|
USA
|
300.00M
|
|
154
|
Arrowhead Research Corp.
|
USA
|
298.10M
|
|
155
|
Oncothyreon Inc
|
USA
|
294.19M
|
|
156
|
Immune Design Corp.
|
USA
|
292.69M
|
|
157
|
Affimed N.V.
|
Germany
|
289.57M
|
|
158
|
Lion Biotechnologies, Inc.
|
USA
|
289.27M
|
|
159
|
Sinovac Biotech Ltd.
|
China
|
289.15M
|
|
160
|
Foamix Pharmaceuticals Ltd.
|
Israel
|
289.07M
|
|
161
|
CTI BioPharma Corp.
|
USA
|
289.04M
|
|
162
|
ChemoCentryx, Inc.
|
USA
|
285.57M
|
|
163
|
Threshold Pharmaceuticals Inc.
|
USA
|
279.65M
|
|
164
|
Anthera Pharmaceuticals, Inc.
|
USA
|
277.90M
|
|
165
|
Nivalis Therapeutics, Inc.
|
USA
|
271.46M
|
|
166
|
KemPharm, Inc.
|
USA
|
264.82M
|
|
167
|
Avalanche Biotechnologies, Inc.
|
USA
|
260.40M
|
|
168
|
NanoString Technologies, Inc.
|
USA
|
260.21M
|
|
169
|
Egalet Corporation
|
USA
|
258.87M
|
|
170
|
Compugen Ltd.
|
Israel
|
258.60M
|
|
171
|
Tokai Pharmaceuticals, Inc.
|
USA
|
251.88M
|
|
172
|
InVivo Therapeutics Holdings Corp.
|
USA
|
251.46M
|
|
173
|
Synta Pharmaceuticals Corp.
|
USA
|
251.05M
|
|
174
|
Cellular Biomedicine Group Inc.
|
USA
|
249.64M
|
|
175
|
Applied Genetic Technologies Corporation
|
USA
|
249.33M
|
|
176
|
Cytokinetics, Incorporated
|
USA
|
246.06M
|
|
177
|
Navidea Biopharmaceuticals, Inc
|
USA
|
245.67M
|
|
178
|
Sequenom Inc.
|
USA
|
242.86M
|
|
179
|
Galena Biopharma, Inc.
|
USA
|
242.58M
|
|
180
|
Trevena, Inc.
|
USA
|
242.00M
|
|
181
|
Verastem, Inc.
|
USA
|
238.74M
|
|
182
|
Flex Pharma, Inc.
|
USA
|
238.24M
|
|
183
|
Veracyte, Inc.
|
USA
|
229.66M
|
|
184
|
BioTime, Inc.
|
USA
|
227.33M
|
|
185
|
Peregrine Pharmaceuticals, Inc.
|
USA
|
227.29M
|
|
186
|
Tobira Therapeutics, Inc.
|
USA
|
224.28M
|
|
187
|
Proteon Therapeutics Inc
|
USA
|
217.93M
|
|
188
|
Dicerna Pharmaceuticals, Inc.
|
USA
|
217.22M
|
|
189
|
Corium International, Inc.
|
USA
|
215.17M
|
|
190
|
Endocyte, Inc.
|
USA
|
211.16M
|
|
191
|
Evogene Ltd.
|
Israel
|
210.74M
|
|
192
|
Enzymotec Ltd.
|
Israel
|
204.39M
|