That is the slow growth of cells under laboratory conditions is still limited and scientists did a treatment of cell drugs expensive and inaccessible.
The study was made by fibroblasts — connective tissue cells that play an important role in wound healing. The activator was made by a colloidal solution (Sol) of nanoparticles of cerium dioxide, synthesized in the Institute of General and inorganic chemistry im.
Stress management
«When growing cells in vitro, i.e., outside the body, creates suboptimal conditions. In vitro increased levels of oxygen compared to conditions in vivo, which affects the metabolism of cells. In particular, they develop oxidative stress. The addition of nanoparticles СеО2 reduces the level of oxidative stress, thereby mimicking normal growth conditions in the body. Culture of stem cells begins to grow faster," explained the main idea of the study, research Manager, Junior researcher of the laboratory of cell growth and tissue ITEB Anton Popov.
He said TASS that the results of studies on mouse fibroblasts was published in may in the journal Materials Science and Engineering C: «In mice, we first showed that these molecular mechanisms are even possible». And the most recent work, which describes the influence of nanoparticles СеО2 already on human cells, was published in the December issue of Nanomechanics Science and Technology: An International Journal. She tells him about the experiments of the group of death of mesenchymal stem cells isolated from the pulp of human teeth and umbilical cord of newborns.
In addition to scientists from ITEB RAS and Institute name kurnakova, the study was attended by representatives of National research Tomsk state University and
Work on the study of fibroblasts were held in the framework of grants of the Russian Foundation for basic research, Russian science Foundation and the Moscow government.
The law on cell therapy
The study group Popov is especially important due to the fact that on 1 January in Russia came into force a law on biomedical cell products, which allows the use of live cells for therapy. In contrast transplantation in the treatment cells of the patient’s body not rejecting the obtained biomaterial.
In Russia, officially it is possible to use cell therapy
Biomedical cell products is fundamentally different from medicines and medical devices. To obtain such products from the donor organism is taken a piece of material a few millimeters in size. «In the process of cell production scale, modify, combine with some other drugs, and in the production process there is a new quality — biomedical cell product. Given the current technological capabilities of small biopsy material (material obtained by biopsy) of the skin can to neurons or heart cells. The possibilities here are limitless,« — said TASS, one of the developers of the law, the Director of the Institute of biology of development.
