In regenerative medicine, in particular in the treatment of burns, one of the main tasks is the efficient recovery of damaged skin tissues and prevent scarring. Scars are formed whenever the skin is severely affected, beyond the outer layer of the skin, whether a cut, a burn, skin diseases such as acne or fungal infection.
Scarface: why do I get scars and how to deal with it© RIA Novosti / A. Filippovtsy, towering above the skin, hypertrophic scars are formed due to active production of collagen. Injection enzymes help remove excess amount of scar tissue.
© RIA Novosti / A. Filippovtsy, towering above the skin, hypertrophic scars are formed due to active production of collagen. Injection enzymes help remove excess amount of scar tissue.© RIA Novosti / A. Filippovskaya feeding fresh tripe, give it a pink hue. The effects of the dye laser scar returns the color of healthy skin, reduce its height and density.
© RIA Novosti / A. Filippovskaya feeding fresh tripe, give it a pink hue. The effects of the dye laser scar returns the color of healthy skin, reduce its height and density.© RIA Novosti / A. Filippoupolitis of keloid scars has not been studied to the end. Sprawling in different directions, the scar tissue is difficult to remove. Surgical intervention may lead to relapse, so to remedy the defect patients conducting a course of injections of hormonal drugs.
© RIA Novosti / A. Filippoupolitis of keloid scars has not been studied to the end. Sprawling in different directions, the scar tissue is difficult to remove. Surgical intervention may lead to relapse, so to remedy the defect patients conducting a course of injections of hormonal drugs.© RIA Novosti / A. F. the site of the inflammation caused by acne, scarring and stagnant spots. Similar defects are removed vascular laser.
© RIA Novosti / A. F. the site of the inflammation caused by acne, scarring and stagnant spots. Similar defects are removed vascular laser.© RIA Novosti / A. Filippovskijj burn injury is extensive scarring that can restrict movement and disturb the work of the organs. In the treatment of such skin lesions combined surgical approach and laser effects.
© RIA Novosti / A. Filippovskijj burn injury is extensive scarring that can restrict movement and disturb the work of the organs. In the treatment of such skin lesions combined surgical approach and laser effects.© RIA Novosti / A. Filippovaracalli method for treatment of extensive scarring – fractional photothermolysis. The effects of laser beams of different lengths partially destroys scar tissue and stimulates skin regeneration.
© RIA Novosti / A. Filippovaracalli method for treatment of extensive scarring – fractional photothermolysis. The effects of laser beams of different lengths partially destroys scar tissue and stimulates skin regeneration.© RIA Novosti / A. Filippovka other treatments have no effect, some types of scarring can be eliminated with surgical excision.
© RIA Novosti / A. Filippovka other treatments have no effect, some types of scarring can be eliminated with surgical excision.© RIA Novosti / A. Filippovtsy are formed not only after injuries, but also as a result of pathological processes in the organism and transferred dermatological diseases. A qualified doctor will determine the cause of the scar, its appearance and will prescribe the best treatment regimen.
© RIA Novosti / A. Filippovtsy are formed not only after injuries, but also as a result of pathological processes in the organism and transferred dermatological diseases. A qualified doctor will determine the cause of the scar, its appearance and will prescribe the best treatment regimen. / Scar tissue consists mainly of unidirectional collagen and is significantly different from the tissue that it replaces, the reduced functional properties. For example, scars on the skin more sensitive to ultraviolet radiation, not elastic, they do not regenerate sweat glands and hair follicles.
In the solution of the problem of scarring has joined the staff of the laboratory «Inorganic nanomaterials» nust «Misa», who managed to create multiple layers of «bandage» from polycaprolactone biodegradable fibers and multi-functional bioactive nanofilms with specified mechanical properties and high biocompatibility. The antibacterial effect by the introduction of silver nanoparticles or accession of antibiotics, and increase of the biological activity by application to the surface of hydrophilic groups (-COOH) and the plasma proteins have provided material unique healing properties.
© Press service of the nust «MISIS»Burn bandages, which need not be removed
© Press service of the nust «MISIS»Burn bandages that do not need slimtype applied to the injured area bandage of developed material, there is a significant acceleration of the healing process, the successful regeneration of normal epithelial tissues of skin and prevent the formation of scar burnt or damaged fragment. Antibacterial components multifunctional nanofibers reduce inflammation and blood plasma with a high content of platelets, a critical and universal element in the healing process – stimulates the regeneration of tissues. Dressing in the course of treatment need not be removed and replaced, causing additional pain to the patient. After a certain period of the biodegradable fiber is simply «dissolves» in the organism without side effect.
«We managed through chemical bonds to create a stable layer containing components of blood plasma (growth factors, fibrinogen and other important proteins contribute to cell growth) on polycaprolactone substrate. The base fiber was synthesized by electrotorture, – says one of the participants of the project, postgraduate student of laboratory of Elizabeth Permyakova. – Then, using a plasma treatment on the surface deposited polymer layer containing a carboxyl group, in order to increase the hydrophilic properties of the material. The resulting layer was enriched antibacterial and protein components.»
At this moment, the team already conducted a series of preclinical tests, together with the research Institute of experimental and clinical medicine in Novosibirsk. Results in vitro showed that the application of innovative dressings the process of cell regeneration is accelerated in two times. Soon the team is awaiting results of testing of the drug in vivo.
