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Professor A.V.Kabashin: oncology to be defeated by nanoteranostics

How has the idea to create a separate Engineering physical institute of biomedicine appeared?

Institute of biomedicine is one of 5 MEPhI new structural units, created in a new multidisciplinary trend. In the Soviet Union education was separated from science: education was done in institutes, science — in the RAS. In Russia all the institutes suddenly became universities, but the gist has not changed: the system of faculties and departments is aimed not at scientific research, but at students’ education at different faculties.

MEPhI new structural units are research institutes on the basis of the university. In such universities students have a possibility not only to study, but also to participate in published and financed scientific research. Such system allows professors develop while teaching students.

Why is the main scientific focus on the biomedicine?

For the past 10–15 years the focus of scientific interests has moved from physics, mainly concentrating on defense needs, to the sciences about health. People are ready to put a lot of money either in safety or in health. Such trend supposes the development of brand new interdisciplinary directions: physics, chemistry, biology, materials sciences, engineering. Sciences mix, and such symbiosis creates new technologies, methods, devices for biomedical application.
Specialists in biomedicine are in demand all over the world. In positron-emission tomography medical education is not enough, engineering education is required with an incline to biomedicine.

In MEPhI Obninsk branch the medical faculty has always been good. Now the idea of uniting Obninsk educational basis with MEPhI nuclear medicine is being realized.

What does modern nuclear medicine look like?

This is a huge area of high-technology medicine, in which radiation of radionuclides and other sources is used, and also beams of accelerated ionizing particles (for example, protons) for curing and diagnostics of diseases, in particular, oncological ones. Cancer is our main enemy, more than 13% of deaths are caused by it.

Positron-emission tomography is unique because it allows record molecular-biological changes before organic anatomical changes happened, which very important for early tumor detection. On the other hand, betta and gamma radiation of some radionuclides turns out be very effective for selective destruction of cancer cells and oncological diseases’ treatment.

There are currently a lot of talks about proton therapy. Is it really an effective direction?
Yes, there is a real boom of this kind of therapy all over the world, such systems are set everywhere. Russia falls a bit behind in that sense, but there are unique developments, which allow make proton accelerators and treatment systems on their basis cheaper.

Proton facilities are good in a way that they allow get a 3D picture on tumor localization, after which proton sources influence the tumor pointwise. This is especially effective for fighting of such aggressive oncological diseases as brain and eye-ball’ tumors.

In Russia nuclear medicine has long been realized in concrete developments, but very few knew about it, because Russian scientists were seldom published in scientific journals. Russian science was isolated from the rest of the world.

Was it one of the reasons of your leaving the country in 90s?

I wasn’t ready to be disqualified by specialization because of patriotism despite loving my motherhood. I managed not only to become a part of the western scientific system, but also define its success in North America and then in Europe.


Now the main task of people like me, coming back to Russia, is to teach talented youth work at the modern level of the world science and as a part of international system. In other words, learn to play and win at the international scientific field following its rules.

We have many specialists of high category and good developments. We have great practice in nanotechnologies, nanophotonics for biomedical applications. We also have developments in equipment for positron-electronic tomography, a series of developed unique radionuclides, which are used for diagnostics and therapy of oncological diseases.

In which field do you expect the greatest breakthrough in the nearest future?
In our view, the most perspective could be uniting nanotechnologies with the results in nuclear medicine. The gist is to deliver radionuclides in the tumor field, not harming other tissues. The radionuclides’ delivery is the main problem of nuclear medicine. They live only 2–3 hours, and they should spend this time not in the blood flow, but in the place of tumor. This is where we expect the greatest breakthrough.

How can it be achieved technically?

For example, if we take one biocompatible and biodegradable nanoparticle, for example, a silicone one — the safest of all non-organic materials, place a radionuclide, for example, rhenium-188 on it, the particle takes it to the place of tumor localization. The radionuclide heals the tumor, then the particle dissolves and leaves the organism through kidneys, with urine, without any side effects. There nanoparticles are used as containers for radiopharmaceuticals’ delivery to destroy cancer tumours.

Our global aim, nanoteranostics, is a mixture of diagnostics and therapy in the nanosize scale.

The nanoparticle localization will allow cure the organism in a way as not to harm it. Chemotherapy and radiation therapy often destroy everything, people die not of the cancer, but of its treatment’ consequences. Nanoteranostics will help avoid it.

Source: https://eng.mephi.ru/news/119501

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