Gut bacteria can produce a
Excessive blood clotting limits or blocks blood flow which can cause heart attack, stroke, damage to the body’s organs or death.
The new study provides the first direct evidence in humans that consuming excess choline, an essential nutrient plentiful in a Western diet, raises both levels of the
In this small study, 18 volunteers (8 vegan or vegetarian, 10 omnivores) without heart disease or major risk factors (average age 46 years, 40 percent male), took supplements of 500 milligrams (mg) of choline bitartrate twice daily for two months. The average daily intake is about 302 mg a day.
Researchers found:
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Blood levels of TMAO rose more than 10 times after both 1 and 2 months of choline supplementation in both vegans/vegetarians and omnivores alike.
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The tendency of platelets to form clots in a laboratory test rose with choline supplementation.
The ability of elevated TMAO levels to promote clot formation was reduced when subjects were also taking a daily baby aspirin (81 mg/day). -
«Foods that raise TMAO may increase your risk for clotting and thrombotic events. Unless prescribed by your doctor, avoid supplements with choline. A Mediterranean or vegetarian diet is reported to help reduce TMAO," said Stanley L. Hazen, M.D., Ph. D., senior author of the study, chair of Cellular and Molecular Medicine, and section head of Preventive Cardiology & Rehabilitation at the Cleveland Clinic in Ohio.
The National Institutes of Health and the Office of Dietary Supplements funded the study.
