Turning Foe to Friend: Stem Cell Treatment Mediates Harmful Immune Response Following Spinal Cord Injury in Pre-Clinical Trials
When a blunt-force blow injures the spinal cord, the body’s immune system can be both friend and foe. Sensing the injury, the immune system dispatches an inflammatory response composed of specialized cells called macrophages to dispose of dead tissue. However, together with the debris and blood from the initial injury, the macrophages also clear away healthy tissue, resulting in a larger lesion size at the injury site and additional spinal cord injury loss of function.