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Question:
Gerontology
Do you think there will be significant breakthroughs in longevity research in the next decade?
The answer by DR. Ancha Baranova
School of Systems Biology, David King Hall, MSN 3E1 George Mason University Associate Professor, School of Systems Biology, David King Hall, MSN 3E1 George Mason University
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Absolutely — but with them will come a realization that these 1) solutions are not available to everybody 2) too late for some people — and it will stem a lot of debates in politics and society the primary means of life extension will be in 1) metabolism manipulations 2) microbiome manipulation 3) nutraceuticals will be mass-market and will be used as middle class quazi treatments.
Question:
Gerontology
Will the use of stem cells useful in the future?
Regenerative approaches and stem cell therapies continue to appear promising and there will also likely be translational applications in stem cell therapies for promoting healthspan, although the impact on longevity from such treatments is less clear with little evidence that it is possible to extend lifespan in this way.
Question:
Gerontology
Can dieting make life longer? What is the best diet to choose?
The answer by Luigi Fontana
Washington University MD, PhD Department of Internal Medicine Division of Geriatrics and Nutritional Sciences Center of Human Nutrition Washington University
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It has been clearly shown that dietary restriction is one of the most powerful intervention to slow ag
Nowadays, the concept of «dietary restriction» is an important intervention to promote human health is well accepted in the scientific community (Fontana et al., Science 2010; Fontana & Partridge. Cell 2015)
Similarly, I was one of the first scientists to suggest the importance of lowering protein intake as a key intervention for the down-regulation of the pro-aging and pro-cancer IGF-1/mTOR pathway in humans (Fontana et al., Aging Cell 2008; Fontana et al., Oncotarget 2013)