Developers
Dominic J Hare, Bárbara Rita Cardoso, Erika P Raven,
Description of the technology
Iron accumulates gradually in the ageing brain. In Parkinson’s disease, iron deposition within the substantia nigra is further increased, contributing to a heightened
The developers of the technology have hypothesized that people in
The authors have proposed to (a) validate a retrospective biomarker of iron exposure in children; (b) translate this biomarker to adults; © integrate it with in vivo brain iron value in Parkinson’s disease; and (d) longitudinally examine the relationships between
Practical application
This approach will provide empirical evidence to support therapeutically addressing brain iron deposition in Parkinson’s diseases and produce a potential biomarker of Parkinson’s disease risk in preclinical individuals.
The technology will be highly valuable for prevention, diagnostics and treatment of Parkinson’s disease. Besides, it will help to improve the quality of diet in the various groups of human population, especially in early ages.
Laboratories
- Department of Medicine (Royal Melbourne Hospital) at the Doherty Institute, The University of Melbourne, Melbourne (Australia)
- The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne (Australia)
- Elemental
Bio-imaging Facility, University of Technology Sydney (Australia) - Department of Pharmaceutical Sciences, Department of Food and Experimental Nutrition, University of São Paulo, São Paulo (Brazil)
- Victorian Infectious Diseases Service, Royal Melbourne Hospital, Melbourne (Australia)
Links
http://www.nature.com/articles/s41531-Publications
- Hare, D.J. et al. «Excessive
early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson’s disease." 3 NPJ Parkinson’s Disease, (2017): 1. - Hare, D. J. & Double, K. L. «Iron and dopamine: a toxic couple." 139 Brain, (2016): 1026–1035.
- Hare, D. J. et al. «Is
early-life iron exposure critical in neurodegeneration?» 11 Nat. Rev. Neurol, (2015): 536–544.