Developers
Xianli Wang, Chuanming Dong, Lixin Sun, Jinfu Zhang, Jun Xu, etc.
Description of the technology
Aging is characterized by a progressive decline in the function of adult tissues, which can lead to neurodegenerative disorders. However, little is known about the correlation between protein changes in the subventricular zone and neurodegenerative diseases with age.
In this technology, these correlations were studied by proteomic analysis. Neural stem cells were derived from the subventricular zone on postnatal 7 d, 1 m, and 12
Taken together, these findings provided valuable insight into the cellular and molecular processes that underlie
Practical application
This technology can be highly valuable for the early detection of differences in gene expression and the potential risk of neurological diseases. It can be beneficial in the investigation, prevention and early start of treatment of these diseases.
Laboratories
- East Hospital, Tongji University School of Medicine, Shanghai (China)
- Department of Anatomy, Nantong University, Nantong, Jiangsu (China)
- Department of Neuroscience, Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield (UK)
- Department of Urology, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai (China)
Links
http://www.nature.com/articles/srep37443Publications
- Wang, X. et al. «Quantitative proteomic analysis of
age-related subventricular zone proteins associated with neurodegenerative disease." 6 Scientific Reports, (2016): 37443. - Dong, C. M. et al. «A
stress-induced cellular aging model with postnatal neural stem cells." 5 Cell Death Dis, (201 $): e1116.