Developers
Parthasarathy Chandrakesan, Randal May, Michael S. Bronze, Courtney W. Houchen, etc.
Description of the technology
Crypt epithelial survival and regeneration after injury require highly coordinated complex interplay between resident stem cells and diverse cell types. The function of Dclk1 expressing tuft cells regulating intestinal epithelial DNA damage response for cell survival/
Practical application
These findings may give new insight into the functional role of Dclk1 expression in tuft cells in maintaining cell and genome integrity and survival for epithelial remodeling and cell fate decision after injury. Specific pharmacological activation of Dclk1 expression in tuft cells could form a new technology for treatment of severe injuries, for example, radiation traumas.
Laboratories
- Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City (USA)
- OU Cancer Institute, University of Oklahoma Health Sciences Center, Oklahoma City (USA)
- Department of Veterans Affairs Medical Center, Oklahoma City (USA)
Links
http://www.nature.com/articles/srep37667Publications
- Chandrakesan, P. et al. «Intestinal tuft cells regulate the ATM mediated DNA Damage response via Dclk1 dependent mechanism for crypt restitution following radiation injury." 6 Scientific Reports, (2016): 37667.
- Chandrakesan, P. et al. «Dclk1+ small intestinal epithelial tuft cells display the hallmarks of quiescence and
self-renewal ." 6 Oncotarget, (2015): 30876–30886. - Chandrakesan, P. et al. «Utility of a bacterial infection model to study
epithelial-mesenchymal transition,mesenchymal-epithelial transition or tumorigenesis." 33 Oncogene, (2014): 2639–2654.