Developers
Assaf Malik, Vered Domankevich, Aaron Avivi, Imad Shams, etc.
Description of the technology
The subterranean blind mole rats (the genus Spalax), experience acute
To study this apparent paradox, authors of the technology utilized a computational procedure that allows detecting differences in transcript abundance between Spalax and the closely related
Practical application
This technology can be very useful for study of ageing processes. It will help to investigate the deepest and sophisticated mechanisms of ageing.
This study allowed to determine that the involvement of genes related to genome maintenance, and DNA repair and replication, protects Spalax against damage induced by oxygen fluctuations, and may also be associated with its longevity and cancer resistance.
The approaches, which underlie this technology, enable to compare the related
Laboratories
- Institue of Evolution, University of Haifa, Haifa (Israel)
- Bioinformatics Core Unit, University of Haifa, Haifa (Israel)
- Deparment of Evolutionary and Environmental Biology, University of Haifa, Haifa (Israel)
BGI-Tech ,BGI-Shenzhen , Shenzhen (China)
Links
http://www.nature.com/articles/srep38624Publications
- Malik, A. et al. «Genome maintenance and bioenergetics of the
long-lived hypoxia-tolerant andcancer-resistant blind mole rat, Spalax: across-species analysis of brain transcriptome." 6 Scientific Reports, (2016): 38624. - Domankevich,
v. et al. «Adaptive patterns in the p53 protein sequence of the hypoxia- andcancer-tolerant blind mole rat Spalax." 16 BMC Evol Biol, (2016): 177. - Malik, A. et al. «Transcriptome analysis of the spalax hypoxia survival response includes suppression of apoptosis and tight control of angiogenesis." 13 BMC Genomics, (2012): 615.
- Avivi, A. et al. «Increased blood vessel density provides the mole rat physiological tolerance to its hypoxic subterranean habitat." 19 Faseb J, (2005): 1314–1316.