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Bethesda, Md.—Calorie restriction has long been studied as a way to extend lifespan in animals. It has been associated with the ability to reduce the risks of cardiovascular and other diseases and to improve overall health. Now, researchers at Chang Gung University in Taiwan have found that calorie restriction can also be beneficial to muscles, improving muscle metabolism and mass at an important time—during middle age. The article “Late-onset Caloric Restriction Alters Skeletal Muscle Metabolism by Modulating Pyruvate Metabolism” is published ahead of print in the American Journal of Physiology–Endocrinology and Metabolism.