NeuroPhage’s NPT088 Universally Targets Misfolded Proteins in Preclinical Studies Highlighted in Oral Session at the Alzheimer’s Association International Conference
NeuroPhage Pharmaceuticals, Inc. today announced that the discovery, preclinical development and clinical trial approach for its lead candidate, NPT088, were highlighted in an oral session at the Alzheimer’s Association International Conference (AAIC) taking place July 18–23, 2015, in Washington, D.C. NPT088 contains the general amyloid interaction motif (GAIM), which allows the compound to universally recognize and disrupt the shape of misfolded proteins and target them for degradation through the body’s natural mechanisms. In the data presented at AAIC, administration of NPT088 led to broad beneficial effects in animal models of Alzheimer’s and Parkinson’s diseases, with improvements in memory and cognition and reductions in toxic protein aggregates.