Bethesda, Md.—Calorie restriction has long been studied as a way to extend lifespan in animals. It has been associated with the ability to reduce the risks of cardiovascular and other diseases and to improve overall health. Now, researchers at Chang Gung University in Taiwan have found that calorie restriction can also be beneficial to muscles, improving muscle metabolism and mass at an important time—during middle age. The article “Late-onset Caloric Restriction Alters Skeletal Muscle Metabolism by Modulating Pyruvate Metabolism” is published ahead of print in the American Journal of Physiology–Endocrinology and Metabolism.
«To date, caloric restriction (CR) is the only
Calorie restriction is thought to have a protective effect on muscle cells and may help cells better use antioxidants, avoid damage caused by free radicals and function better. While studies that observed the effects of lifelong calorie restriction have shown mixed results in animals of different ages, recent studies have suggested that age may play a role in how CR affects individual animals. The research team hypothesized that because CR can help reprogram metabolism, the most benefit can be reaped from aging muscles in which cellular metabolism is impaired.
Researchers focused on two pathways that produce energy in muscles, glycolysis (sugar metabolism) and mitochondrial oxidative phosphorylation (OXPHOS) in both young and
«We investigated whether CR reprogrammed muscle metabolism and whether this improvement was associated with the observed increase in muscle mass. In addition, we examined whether the
Not surprisingly, the
The American Physiological Society Press Release