NephroGenex

Link
nephrogenex.com
Название компании
NephroGenex
Phone
(609) 986-17-80
Address
3200 Beechleaf Ct. Suite 900
City
Raleigh
Country
USA
Headquarters
Raleigh, NC 27604
Stage of the project
Startup
Total Raised
$4,300,000
Description

NephroGenex is an innovator in the development of drugs to treat kidney disease, with a first indication in diabetic nephropathy. We have been pioneering the development of PYRIDORIN® (pyridoxamine dihydrochloride), a late stage compound to treat the one-third of diabetics with this slow-developing but potentially deadly disease. The key to the therapy’s potential for slowing or stabilizing progression to end stage renal disease is its unique mode of action: the drug scavenges a broad range of the pathogenic oxidative chemistries that are elevated in diabetics and cause kidney damage.

Our clinical and regulatory teams have positioned the Phase 3 PIONEER program for success by securing from the FDA a Fast Track designation and Special Protocol Assessment (SPA) for a new endpoint that will reduce the time, cost and risk of the trial. The SPA also allows for a patient population where Pyridorin previously demonstrated a greater than 50% treatment effect in Phase 2 studies. We believe Pyridorin represents real hope for the 6 million patients with diabetic nephropathy in the U.S. alone who today have no adequate treatments available to them.