Rachael C. Kuintzle, Eileen S. Chow, Jadwiga M. Giebultowicz, David A. Hendrix, etc.
Description of the technology
Disruption of the circadian clock, which directs rhythmic expression of numerous output genes, accelerates aging. To enquire how the circadian system protects aging organisms, the authors of this technology compare circadian transcriptomes in heads of young and old Drosophila melanogaster. The core clock and most output genes remained robustly rhythmic in old flies, while others lost rhythmicity with age, resulting in constitutive over- or
The study, carried out in order to development of this technology, provides first insights into the mechanism of
- Department of Biochemistry & Biophysics, 2011 Agriculture & Life Sciences Building, Oregon State University, Corvallis (USA)
- Department of Integrative Biology, 3029 Cordley Hall, Oregon State University, Corvallis (USA)
- School of Electrical Engineering and Computer Science, 1148 Kelley Engineering Center, Oregon State University, Corvallis (USA)
- Kuintzle, R.C. et al. «Circadian deep sequencing reveals
stress-responsegenes that adopt robust rhythmic expression during aging." 8 Nature Communications (2017): 14529.
- Krishnan, N. et al. «Loss of circadian clock accelerates aging in
neurodegeneration-pronemutants. Neurobiol." 45 Dis. (2012): 1129–1135.
- Krishnan, N. et al. «The circadian clock gene period extends healthspan in aging Drosophila melanogaster." 1 Aging (2009): 937–948.