Shaocheng Ma, En Lin Goh, Ulrich Hansen, Richard L. Abel et al.
Description of the technology
Osteoporosis is one of most important
This paper aims to investigate the effect of bisphosphonate treatment on bone microstructure and mechanical strength. Assessment of microdamage within the trabecular bone core was performed using synchrotron
This technology can be used as a method for assessment of microstructural changes in bones of the patients treated with bisphosphonates. For patients on
The technology is applicable both for experimental investigations in the field of ageing mechanism study, particularly, osteoporosis, and (in prospect) for clinical medicine.
- Department of Mechanical Engineering, Faculty of Engineering, Imperial College London, London (UK)
- MSk Laboratory, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London (UK)
- St. Mary’s Hospital, North West London Major Trauma Centre, Imperial College, London (UK)
- Department of Mechanical Engineering, Faculty of Engineering, University of Moratuwa, Moratuwa (Sri Lanka)
- Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot (UK)
- Ma, S. et al. «
Long-termeffects of bisphosphonate therapy: perforations, microcracks and mechanical properties." 7 Scientific Reports (2017): 43399.
- Ma, S. et al. «Synchrotron Imaging Assessment of Bone Quality." 1 Clinical Reviews in Bone and Mineral Metabolism (2016): 11.
- Karunaratne, A. et al. «Significant deterioration in nanomechanical quality occurs through incomplete extrafibrillar mineralization in rachitic bone: Evidence from
in-situsynchrotron X-rayscattering and backscattered electron imaging." 27 Journal of Bone and Mineral Research (2012): 876–890.